A very nice story, hopefully that will end up as a successful vaccine to help the world to handle Covid pandemic.
Oxford / AstraZeneca vaccine showed different response rate depending of dosing scheme.
In patients who received two full doses, efficacy is evaluated at 62%.
In patients who received a half dose and then a full dose, the efficacy is evaluated at 90%, very close to the other vaccines (Moderna and Pfizer/BioNTech, 94.5% and 95% respectively).
Oxford scientists worked hard on the development of this type of vaccines during long years. And lately, Astrazenzeca teams joined their effort to do so. However, the final touch which makes the difference, the dosing which leads to a better response (Half dose and then a full dose of vaccine candidate) was initially a mistake (seen Reuters article)! Long-life to Serendipity, even in 2020!
The second lesson is that AstraZeneca and Oxford teams showed great quality, they saw something unpredicted, they explored and then they found out the “mistake”.
Serendipity helps, and you still have to do you part.
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